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Jürgen Hesser

Professor for Data Analysis and Modeling in Medicine

Faculty of Medicine Mannheim

Co-opted: Department of Physics and Astronomy

Heidelberg University

juergen.hesser@medma.uni-heidelberg.de 

Jürgen Hesser

Introduction

My research:

Inverse Problems with a focus on model-based Machine Learning

My expertise is:

  • Scientific Computing with focus on Inverse Problems

  • Machine Learning methods development

  • Causal modeling

A problem I’m grappling with:

Overcoming hard problems of applying machine learning in scientific computing such as using PINNs for stiff differential equations

I’ve got my eyes on:

Mathematical foundations on ML

I want to know more about:

Incorporating combining the physics with ML

Projects

Physics Model-Based AI for Rare Events

Develop a novel strategy to perform reliable extrapolation with machine learning (ML) by space-unwrapping; efficiently handle extreme value modelling via machine learning using model-based strategies like exponentially tiled estimators; solve stochastic partial differential equations via physics informed neural networks for transport equations.

Denoising diffusion probabilistic models

Develop novel methods of inverse problem solutions based on denoising diffusion probabilistic models; investigate new approaches to uncertainty estimation based on stochasticity of denoising diffusion models; introduce new techniques of conditional generation based on concatenation, cross-attention and bias.

New Generative Models for Parton Distributions

The goal of the project is to switch from the current situation, in which a hyperoptimized machine learning model leads to results whose accuracy is tested a posteriori, to interpretable models in which the relation between experimental, theoretical and modeling uncertainty and the uncertainties in the final outcome can be traced using explainable AI tools.